A100800 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 105.000.0
2.5mg
$ 145.000.0
5mg
$ 175.000.0
10mg
$ 305.000.0
25mg
$ 605.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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A100800

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Product Description

Catalogue NumberA100800
Chemical NameA-1155463 Hydrochloride
Synonyms2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic Acid Hydrochloride;
Alternate CAS #Free Base: 1235034-55-5
Molecular FormulaC₃₅H₃₂FN₅O₄S₂•HCl
AppearanceBeige Solid
Melting Point>140°C (dec.)
Molecular Weight669.79 +(36.46)
Storage-20°C Freezer, Under inert atmosphere
SolubilityChloroform (Slightly, Heated), DMSO (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsA-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killi
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
ReferencesZhang, H., et al.: Mol. Cancer, 14, 1 (2015); Tao, Z., et al.: ACS Med. Chem. Lett., 5, 1088 (2014)