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Pack Size Quantity Price (USD) Sub Total
1mg
$ 110.00 0.0
2.5mg
$ 150.00 0.0
5mg
$ 180.00 0.0
10mg
$ 320.00 0.0
25mg
$ 640.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Inventory Status : Pending QC

Bulk Order Request for A100800

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Product Description

Catalogue Number: A100800
Chemical Name: A-1155463 Hydrochloride
Synonyms: 2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic Acid Hydrochloride;
Alternate CAS #: Free Base: 1235034-55-5
Molecular Formula: C₃₅H₃₂FN₅O₄S₂•HCl
Appearance: Beige Solid
Melting Point: >140°C (dec.)
Molecular Weight: 669.793646
Storage: -20°C Freezer, Under inert atmosphere
Solubility: Chloroform (Slightly, Heated), DMSO (Slightly)
Category: Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, kil
Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References
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