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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 1mg | $ 133.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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A100800
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Product Description
| Catalogue Number | A100800 |
| Chemical Name | A-1155463 Hydrochloride |
| Synonyms | 2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic Acid Hydrochloride; |
| Alternate CAS # | Free Base: 1235034-55-5 |
| Molecular Formula | C₃₅H₃₂FN₅O₄S₂•HCl |
| Appearance | Beige Solid |
| Melting Point | >140°C (dec.) |
| Molecular Weight | 669.79 +(36.46) |
| Storage | -20°C, Inert atmosphere |
| Solubility | Chloroform (Slightly, Heated), DMSO (Slightly) |
| Category | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killi |
| Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package | |
| References | Zhang, H., et al.: Mol. Cancer, 14, 1 (2015); Tao, Z., et al.: ACS Med. Chem. Lett., 5, 1088 (2014) |