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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 145.00||0.0|
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|Chemical Name||A-1155463 Hydrochloride|
|Synonyms||2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic Acid Hydrochloride;|
|Alternate CAS #||Free Base: 1235034-55-5|
|Melting Point||>140°C (dec.)|
|Molecular Weight||669.79 +(36.46)|
|Storage||-20°C, Inert atmosphere|
|Solubility||Chloroform (Slightly, Heated), DMSO (Slightly)|
|Category||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications||A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killi|
|Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package|
|References||Zhang, H., et al.: Mol. Cancer, 14, 1 (2015); Tao, Z., et al.: ACS Med. Chem. Lett., 5, 1088 (2014)|