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|Product Name:||anti- Aconitase 2 antibody|
|Storage:||PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)|
|Background:||ACO2(aconitate hydratase, mitochondrial) is also named as citrate hydro-lyase and belongs to the aconitase/IPM isomerase family. It plays a key function in cellular energy production, and loss of its activity has a major impact on cellular and organismal survival. Western blot shows two bands of 83 kDa and 40 kDa. The 40 kDa fragment decreases with age and oxidative stress, whereas other fragmentation products with molecular weights between 40 and 83 kDa increased with age and MnSOD(mitochondrial manganese superoxide dismutase) deficiency(PMID:12459471). Defects in ACO2 are the cause of infantile cerebellar-retinal degeneration (ICRD).|
|Immunogen:||aconitase 2, mitochondrial|
|Synonyms:||Gene symbol ACO2 Synonyms ACO2, Aconitase, aconitase 2, aconitase 2, mitochondrial, ACONM, Citrate hydro lyase|
|Specificity:||Human, Mouse ,Rat|
|Tested Application:||ELISA, WB, IHC|
|Recommended Dilution:||WB :1:500-1:5000;IHC:1:20-1:200|
|IHC Dilution:||Immunohistochemistry of paraffin-embedded human lung cancer using ACO2 antibody at dilution of 1:50|
|WB Dilution:||human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with ACO2 antibody at dilution of 1:400|