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Pack Size Quantity Price Sub Total
50μg
$ 170.00 0.0
100μg
$ 275.00 0.0
Total $ 0.0
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Product Description

Catalogue Number: AN00084
Product Name: anti- ACK1 antibody
Form: liquid
Host: Rabbit
Clonity: polyclonal
Isotope: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background: TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. The 60-70kd band is the isoform 2 of TNK2. Isoform 1 and 3 is about 120-125kd.
Immunogen: tyrosine kinase, non-receptor, 2
Synonyms: TNK2, ACK1, ACK, FLJ45547, ACK 1
Calculated MW: 115kDa,observed 70kDa
Specificity: human, Mouse , rat
Tested Application: ELISA, WB, IHC
Recommended Dilution: WB :1:200-1:2000;IHC:1:20-1:200
IHC Dilution: Immunohistochemistry of paraffin-embedded human breast cancer using ACK1 antibody at dilution of 1:50
WB Dilution: SH-SY5Y cells were subjected to SDS PAGE followed by western blot with ACK1 antibody at dilution of 1:500
Location: widely
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