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|Product Name:||anti- ACK1 antibody|
|Storage:||PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)|
|Background:||TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. The 60-70kd band is the isoform 2 of TNK2. Isoform 1 and 3 is about 120-125kd.|
|Immunogen:||tyrosine kinase, non-receptor, 2|
|Synonyms:||TNK2, ACK1, ACK, FLJ45547, ACK 1|
|Calculated MW:||115kDa,observed 70kDa|
|Specificity:||human, Mouse , rat|
|Tested Application:||ELISA, WB, IHC|
|Recommended Dilution:||WB :1:200-1:2000;IHC:1:20-1:200|
|IHC Dilution:||Immunohistochemistry of paraffin-embedded human breast cancer using ACK1 antibody at dilution of 1:50|
|WB Dilution:||SH-SY5Y cells were subjected to SDS PAGE followed by western blot with ACK1 antibody at dilution of 1:500|