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Product Description

Catalogue Number: AN00076
Product Name: anti- ACD antibody
Form: liquid
Host: Rabbit
Clonity: polyclonal
Isotope: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Immunogen: adrenocortical dysplasia homolog ( Mouse )
Synonyms: ACD, PIP1, PTOP, TINT1, TPP1
Calculated MW: 58kDa
Specificity: Human
Tested Application: ELISA, WB
Recommended Dilution: WB :1:500-1:5000
WB Dilution: Jurkat cells were subjected to SDS PAGE followed by western blot with ACD Antibody at dilution of 1:1500
Gene ID: 65057
Location: Chromosome, Nucleus, Telomere
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