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|Product Name:||anti- ABL2 antibody|
|Storage:||PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)|
|Background:||Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association wit|
|Immunogen:||v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)|
|Synonyms:||Abelson related gene protein, ABL2, ABLL, ARG, FLJ22224, FLJ31718, FLJ41441, Tyrosine protein kinase ABL2, Tyrosine protein kinase ARG|
|Specificity:||Human, Mouse ,Rat|
|Tested Application:||ELISA, WB, IF, IHC, IP|
|Recommended Dilution:||WB :1:500-1:5000;IHC:1:20-1:200;IF:1:10-1:100;IP:1:200-1:2000|
|IHC Dilution:||Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using ABL2 Antibody at dilution of 1:50|
|WB Dilution:||HeLa cells were subjected to SDS PAGE followed by western blot with ABL2 antibody at dilution of 1:500|