Catalogue number: Z150000
Chemical name: Zaprinast
Synonyms: 3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one; 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one; 8-Aza-2-(2-propoxyphenyl)-6-purinone; M&B 22,948;
CAS Number: 37762-06-4
Possible CAS #: NA
Molecular form.: C₁₃H₁₃N₅O₂
Appearance: Pale Pink to Pink Solid
Melting Point: 229-233°C (dec.)
Mol. Weight: 271.3
Storage: -20˚C Freezer
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of atrial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.
Dangerous Goods Info: NA
References: Burns, F., et al.: Biochem. J., 238, 487 (1992), Lugnier, C., et al.: Am. J. Physiol., 262, H654 (1992),
Peer Review Product Citations:

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