Y 11

Catalogue number: Y100200
Chemical name: Y 11
Synonyms: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane Bromide;
CAS Number: 1086639-59-9
Possible CAS #: NA
Molecular form.: C₈H₁₇BrN₄O
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 265.15
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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