WYE 354-d3

Catalogue number: W950002
Chemical name: WYE 354-d3
Synonyms: 4-[6-[4-[[(Methoxy-d3)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester; WYE-354-d3;
CAS Number: 1794791-66-4
Possible CAS #: unlabelled: 1062169-56-5
Molecular form.: C₂₄H₂₆D₃N₇O₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 498.55
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Boiling Point: No Data Available
Applications: A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 µM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.
Dangerous Goods Info: NA
References: Yu, K. et al.: Cancer Res., 69, 6232 (2009); Zask, A. et al.: J. Med. Chem., 52, 5-13 (2009); Dormind-Meuwly, A. et al.: Biochem. Biophys. Res. Comm., 407, 714 (2011);
Peer Review Product Citations:

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