VU 0357017 Hydrochloride

Catalogue number: V787500
Chemical name: VU 0357017 Hydrochloride
Synonyms: 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride;
CAS Number: 1135242-13-5
Possible CAS #: NA
Molecular form.: C₁₈H₂₈ClN₃O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 369.89
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.
Dangerous Goods Info: NA
References: Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010), Lebois, et al.: ACS Chem. Neurosci., 1, 104 (20010),
Peer Review Product Citations:

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