Catalogue number: U822000
Chemical name: URB754
Synonyms: 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one;
CAS Number: 86672-58-4
Possible CAS #: NA
Molecular form.: C₁₆H₁₄N₂O₂
Appearance: White to Off-White Solid
Melting Point: >202°C (dec.)
Mol. Weight: 266.29
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
Stability: No Data Available
Category: Aromatics, Heterocycles, Inhibitors
Boiling Point: No Data Available
Applications: URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 µM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 µM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 µM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
Dangerous Goods Info: NA
References: Makara, J.K., et al.: Nat. Neurosci., 8, 1139 (2005)
Peer Review Product Citations:

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5mg $45.00
25mg $100.00
100mg $365.00
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10mg $50.00
50mg $195.00
250mg $695.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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