Catalogue number: U700585
Chemical name: UK-356618
Synonyms: (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1’-biphenyl]-4-yl)propyl]butanediamide; UK 356618; PF-03890101;
CAS Number: 230961-08-7
Possible CAS #: NA
Molecular form.: C₃₄H₄₃N₃O₄
Appearance: Beige Solid
Melting Point: 93-102ºC
Mol. Weight: 557.72
Storage: -20˚C Freezer
Solubility: Methanol (Slightly)
Stability: No Data Available
Category: Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
Dangerous Goods Info: NA
References: Fray, M.J. et al.: Bioorg. Med. Chem. Lett., 11, 571 (2001); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003);
Peer Review Product Citations:

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  Pack size Price(USD)
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100mg $795.00
  Pack size Price(USD)
10mg $110.00
50mg $435.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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