(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-7-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadecyl-12,16-dien-5-one

Catalogue number: T876675
Chemical name: (3S,6R,7S,8S,12Z,15S,16E)-1,3,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-7-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadecyl-12,16-dien-5-one
Synonyms:
CAS Number: 193146-49-5
Possible CAS #: NA
Molecular form.: C₄₅H₈₇NO₅SSi₃
Appearance: Colourless Oil
Melting Point: No Data Available
Mol. Weight: 838.5
Storage: No Data Available
Solubility: Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Hexane, Methanol
Stability: No Data Available
Category: Chiral Reagents
Boiling Point: No Data Available
Applications: An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells’ microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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  Pack size Price(USD)
.5mg $125.00
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  Pack size Price(USD)
5mg $1000.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   Pending QC

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