2,2-Dimethylthiopropionamide

Catalogue number: T796135
Chemical name: 2,2-Dimethylthiopropionamide
Synonyms: 2,2-Dimethylpropanethioamide; NSC 381432; Neopentanethioamide; Thiopivalamide
CAS Number: 630-22-8
Possible CAS #: NA
Molecular form.: C₅H₁₁NS
Appearance: White Solid
Melting Point: 114-116ºC
Mol. Weight: 117.21
Storage: Refrigerator
Solubility: Chloroform, Ethyl Acetate
Stability: No Data Available
Category: Amines, Sulfur and Selenium Compounds
Boiling Point: No Data Available
Applications: 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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