Catalogue number: T791320
Chemical name: 2-Trifluoromethyl-2’-methoxychalcone
Synonyms: (2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one;
CAS Number: 1309371-03-6
Possible CAS #: NA
Molecular form.: C₁₇H₁₃F₃O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 306.28
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: 2-Trifluoromethyl-2’-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2’-methoxychalcone is a potent activator of Nrf2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2’-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1.
Dangerous Goods Info: NA
References: Thimmulappa, R., et al.: Cancer Res., 62, 5196 (2002); Rangasamy, T., et al.: J. Exp. Med., 202, 47 (2005); Surh, Y., et al.: Planta Med., 2008, 74, 1526 (2008); Niture, S., et al.: J. Cell Sci., 2009, 122, 4452 (2009);
Peer Review Product Citations:

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