2-(Trifluoromethyl)-benzeneacetonitrile was used to prepare non-peptide CCR1 receptor antagonists. It was also used to synthesize cyclopentimidazopyridinone and related compounds as interleukin-6 inhibitors.
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Ng, H., et al.: J. Med. Chem., 42, 4680 (1999); Tagat, J., et al.: Bioorg. Med. Chem. Lett., 5, 2139 (1995)