TPCA-1

Catalogue number: T700500
Chemical name: TPCA-1
Synonyms: 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide; 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxylic acid amide; IKK 2 Inhibitor IV; TPCA 1
CAS Number: 507475-17-4
Possible CAS #: NA
Molecular form.: C₁₂H₁₀FN₃O₂S
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 279.29
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: TPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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