Tipifarnib

Catalogue number: T444880
Chemical name: Tipifarnib
Synonyms: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-(+)-R 115777; Zarnestra;
CAS Number: 192185-72-1
Possible CAS #: NA
Molecular form.: C₂₇H₂₂Cl₂N₄O
Appearance: Off-White to Pale Beige Solid
Melting Point: 211-213°C (dec.)
Mol. Weight: 489.4
Storage: -20˚C Freezer
Solubility: Chloroform, Methanol
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors,
Boiling Point: No Data Available
Applications: A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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50mg $845.00
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Inventory Status:   In Stock

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