Catalogue number: T425605
Chemical name: D-Thyroxine
Synonyms: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine; 3,3’,5,5’-Tetraiodo-D-thyronine; Dextrothyroxine;
CAS Number: 51-49-0
Possible CAS #: NA
Molecular form.: C₁₅H₁₁I₄NO₄
Appearance: Off-White to Tan Solid
Melting Point: >96°C (dec.)
Mol. Weight: 776.87
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: Acidic Alcohol (Slightly), DMSO (Slightly)
Stability: No Data Available
Category: Amino Acids & Derivatives, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
Dangerous Goods Info: NA
References: Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976), Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988), Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996), Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997),
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