Catalogue number: T350880
Chemical name: (R)-(+)-Thiolactomycin
Synonyms: (5R)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadien-1-yl]-2(5H)-thiophenone; [R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone; (+)-Thiolactomycin; Antibiotic 2-200; Thiolactomycin
CAS Number: 82079-32-1
Possible CAS #: NA
Molecular form.: C₁₁H₁₄O₂S
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 210.29
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: (R)-(+)-Thiolactomycin is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
Dangerous Goods Info: NA
References: Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)
Peer Review Product Citations:

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