Catalogue number: T338200
Chemical name: TH-302
Synonyms: N,N’-Bis(2-bromoethyl)phosphorodiamidic Acid (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl Ester;
CAS Number: 918633-87-1
Possible CAS #: NA
Molecular form.: C₉H₁₆Br₂N₅O₄P
Appearance: Off-White to Pale Yellow Solid
Melting Point: 97-98°C
Mol. Weight: 449.04
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA damage in human cancer cell
Dangerous Goods Info: NA
References: Meng, F. et al.: Mol. Cancer Ther., 11, 740 (2012); Liu, Q. et al.: Cancer Chemother. Pharmacol., 69, 1487 (2012); Sun, J.D. et al.: Clin. Cancer Res., 18, 758 (2012);
Peer Review Product Citations:

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  Pack size Price(USD)
5mg $250.00
50mg $1000.00
  Pack size Price(USD)
10mg $350.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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