Catalogue number: T012000
Chemical name: TC ASK 10
Synonyms: 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-,benzamide Dihydrochloride; 4-tert-Butyl-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide Dihydrochloride
CAS Number: 1005775-56-3
Possible CAS #: 1005775-55-2 free amine
Molecular form.: C₂₁H₂₃Cl₂N₅O
Appearance: White to Off-White Solid
Melting Point: >270° (dec.)
Mol. Weight: 432.35
Storage: Refrigerator, under inert atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: TC ASK 10 is a potent ASK1 inhibitor. It displays selectivity for ASK1 over other kinases including ASK2, MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. It blocks downstream JNK1/p38 phosphorylation in cells.
References: Terao, Y., et al.: Bioorg. Med. Chem. Lett., 22, 7326 (2012)
Dangerous Goods Info: NA

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  Pack size Price(USD)
5mg $175.00
50mg $1375.00
  Pack size Price(USD)
25mg $750.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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