Tamoxifen

Catalogue number: T006000
Chemical name: Tamoxifen
Synonyms: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; Mammaton; Novaldex; Tamoxifen; Z-Tamoxifen; trans-Tamoxifen;
CAS Number: 10540-29-1
Possible CAS #: NA
Molecular form.: C₂₆H₂₉NO
Appearance: White Solid
Melting Point: 92-94°C
Mol. Weight: 371.52
Storage: Amber Vial, -20°C Freezer
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: Light Sensitive
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Boiling Point: No Data Available
Applications: Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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