Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
No Data Available
Isotope labelled TAK-960 is a potent and selective inhibitor of polo-like kinase 1 (PLK1), a serine/threonine protein kinase involved in key processes during mitosis. TAK-960 has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1). TAK-960 treatments has shown significant efficacy against multiple tumor xenografts and is a potential chemotherapeutic agent for patients with advanced tumors.
Dangerous Goods Info:
Hikichi, Y. et al.: Mol. Cancer Ther., 11, 700 (2012); Chen, S. et al.: Bioorg. Med, Chem. Lett., 22, 1247 (2012);