Catalogue number: S885000
Chemical name: Swainsonine
Synonyms: 8α,β-Octahydroindolizidine-1α,2α,8β-triol; (-)-Swainsonine; Tridolgosir; (1S,2R,8R,8aR)-Octahydroindolizidinetriol
CAS Number: 72741-87-8
Possible CAS #: NA
Molecular form.: C₈H₁₅NO₃
Appearance: White to Off-White Solid
Melting Point: >125°C (dec.)
Mol. Weight: 173.21
Storage: -20°C Freezer
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Inhibitors, Glycosidase Inhibitors,
Boiling Point: No Data Available
Applications: Swainsonine is a plant alkaloid derived from Swainsona canescens (a leguminous plant). It is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mM. At acid pH, swainsonine resembles an intermediate in the hydrolysis of mannosidases. Swainsonine completely inhibits mammalian Golgi a-mannosidase II (a-3/6-mannosidase in the glycoprotein processing pathway) and mammalian lysosomal a-mannosidase (acid mannosidase). At higher concentrations, swainsonine also inhibits mammalian cytosolic a-mannosidase. It has been shown to inhibit growth of transformed fibroblasts in soft agar and to enhance the antiproliferative effects of INF on murine lymphoreticular tumor cells in vitro. It also blocks the expression of b1-6 branched complex-type oligosaccharides and
Dangerous Goods Info: NA
References: J. Biol. Chem., 258, 7578-7585 (1983), Methods Enzymol., 98, 135 (1983), EMBO Journal, 3, 551-556 (1984), Mol. Cell. Biol., 5, 3467-3475 (1985), Int. J. Cancer, 44, 685 (1989),Melanoma Res., 1, 43 (1991), Bonay, P., & Fresno, M.: Glycobiology, 9(5), 423-433 (1999), Klein, J-LD, et al.: Br. J. of Cancer, 80(1/2), 87-95 (1999)
Peer Review Product Citations:

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Exact Weight Packaging ($75(USD) / Vial)
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