Sulindac Sulfide

Catalogue number: S699220
Chemical name: Sulindac Sulfide
Synonyms: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid; Sulindac Related Compound C
CAS Number: 49627-27-2
Possible CAS #: NA
Molecular form.: C₂₀H₁₇FO₂S
Appearance: Yellow Solid
Melting Point: 177-182°C
Mol. Weight: 340.41
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO, Methanol (Sparingly)
Stability: Hygroscopic
Category: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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