Sofosbuvir (R)-Phosphate

Catalogue number: S675615
Chemical name: Sofosbuvir (R)-Phosphate
Synonyms: (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; N-[[P(R),2’R]-2’-Deoxy-2’-fluoro-2’-methyl-P-phenyl-5’-uridylyl]-L-alanine 1-Methylethyl Ester
CAS Number: 1190308-01-0
Possible CAS #: NA
Molecular form.: C₂₂H₂₉FN₃O₉P
Appearance: White to Off-White Solid
Melting Point: 76-82°C
Mol. Weight: 529.45
Storage: -20°C Freezer
Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Aceatae (Slightly)
Stability: No Data Available
Category: Heterocycles, Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Dangerous Goods Info: NA
References: Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)
Peer Review Product Citations:

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  Pack size Price(USD)
1mg $95.00
10mg $750.00
  Pack size Price(USD)
2.5mg $195.00
25mg $1775.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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