Catalogue number: S590250
Chemical name: SNX-2112
Synonyms: 4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide; PF 04928473;
CAS Number: 908112-43-6
Possible CAS #: NA
Molecular form.: C₂₃H₂₇F₃N₄O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 464.48
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: SNX-2112 is a selective heat shock protein 90 (Hsp90) inhibitor which can exert a potent anticancer activity. Studies demonstates that SNX-2112 can exhibit a potent anticancer activity against B16 melanoma cells both in vitro and in vivo, by inhibiting cell proliferation and inducing cell cycle arrest and apoptosis in a mechanism dependent on the degredation of Hsp90 client proteins.
Dangerous Goods Info: NA
References: Liu, K.S., et al.: Oncol. Reports., 27, 1904 (2012); Wang, S.X., et al.: BioSci. Biotech. Biochem., 75, 1540 (2011); Bachleitner, H., et al.: Clinical, Cancer, Rsch., 17, 12 (2011);
Peer Review Product Citations:

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