SEN 12333

Catalogue number: S258600
Chemical name: SEN 12333
Synonyms: N-[4-(3-Pyridinyl)phenyl]-4-morpholinepentanamide; WAY 317538;
CAS Number: 874450-44-9
Possible CAS #: NA
Molecular form.: C₂₀H₂₅N₃O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 339.43
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: SEN 12333 is a nicotinic acetylcholine receptor (nAChR) agonist. SEN 12333 displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. SEN 12333 is a brain penetrant and orally bioavailable.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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