Catalogue number: S255600
Chemical name: Semagacestat
Synonyms: (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide; LY 450139;
CAS Number: 425386-60-3
Possible CAS #: NA
Molecular form.: C₁₉H₂₇N₃O₄
Appearance: White Solid
Melting Point: 213-215°C
Mol. Weight: 361.44
Storage: -20˚C Freezer
Solubility: DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (Aβ), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer’s disease (AD).
Dangerous Goods Info: NA
References: Portelius, E. et al.: Alzheim. Res. Ther., 22. No pp. given (2010); Imbimbo, B.P. et al.: Curr. Opin. Invest. Drugs, 10, 721 (2009); Panza, F. et al.: Curr. Med. Chem., 18, 5430 (2011);
Peer Review Product Citations:

Order Product

  Pack size Price(USD)
1mg $35.00
10mg $175.00
  Pack size Price(USD)
5mg $120.00
100mg $1400.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

Search Products:

Enter Catalogue #, CAS # , Chemical Name or Mol Formula:

Search By Category

Search By Category View products by category
Translate »