Catalogue number: S199900
Chemical name: SC-514
Synonyms: 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide; 4-Amino-[2,3’-bithiophene]-5-carboxamide;
CAS Number: 354812-17-2
Possible CAS #: NA
Molecular form.: C₉H₈N₂OS₂
Appearance: Yellow Solid
Melting Point: 209-211°C
Mol. Weight: 224.3
Storage: No Data Available
Solubility: DMSO
Stability: No Data Available
Category: Inhibitors
Boiling Point: No Data Available
Applications: A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
Dangerous Goods Info: NA
References: Kishore, N., et al.: J. Biol. Chem., 278, 32861 (2003)
Peer Review Product Citations: Kishore, N., et al.: J. Biol. Chem., 278, 32861 (2003)

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