SAR131675

Catalogue number: S139510
Chemical name: SAR131675
Synonyms: 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide
CAS Number: 1092538-80-1
Possible CAS #: NA
Molecular form.: C₁₈H₂₂N₄O₄
Appearance: White to Pale Yellow Solid
Melting Point: >206°C (dec.)
Mol. Weight: 358.39
Storage: Refrigerator
Solubility: DMSO (Slightly)
Stability: No Data Available
Category: Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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