SANT-1

Catalogue number: S115000
Chemical name: SANT-1
Synonyms: N-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
CAS Number: 304909-07-7
Possible CAS #: NA
Molecular form.: C₂₃H₂₇N₅
Appearance: Off-White to Pale Yellow Solid
Melting Point: 108-111°C
Mol. Weight: 373.49
Storage: -20°C Freezer
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Inhibitors
Boiling Point: No Data Available
Applications: A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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  Pack size Price(USD)
1mg $45.00
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50mg $425.00
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5mg $80.00
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25mg $285.00
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100mg $775.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock

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