Ro 106-9920

Catalogue number: R637500
Chemical name: Ro 106-9920
Synonyms: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine;
CAS Number: 62645-28-7
Possible CAS #: NA
Molecular form.: C₁₀H₇N₅OS
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 245.26
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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