Romidepsin-d8

Catalogue number: R425062
Chemical name: Romidepsin-d8
Synonyms: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl]-d8 Cyclic (35)-Disulfide; [S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4- heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone-d8 Cyclic (12)-Disulfide; Antibiotic FR 901228-d8; Chromadax-d8; FK 228-d8; FR 901228-d8; NSC 630176-d8;
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₂₄H₂₈D₈N₄O₆S₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 548.75
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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