Romidepsin

Catalogue number: R425060
Chemical name: Romidepsin
Synonyms: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] Cyclic (35)-Disulfide; [S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4- heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone Cyclic (12)-Disulfide; Antibiotic FR 901228; Chromadax; FK 228; FR 901228; NSC 630176;
CAS Number: 128517-07-7
Possible CAS #: NA
Molecular form.: C₂₄H₃₆N₄O₆S₂
Appearance: White to Off-White Solid
Melting Point: 219-224°C
Mol. Weight: 540.7
Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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  Pack size Price(USD)
500µg $80.00
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2mg $225.00
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10mg $725.00
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  Pack size Price(USD)
1mg $125.00
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5mg $375.00
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25mg $1800.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock

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