Regorafenib N-Demethyl-N-4-(3-fluoro-4-methylphenoxy)-N-methylpicolinamide

Catalogue number: R143005
Chemical name: Regorafenib N-Demethyl-N-4-(3-fluoro-4-methylphenoxy)-N-methylpicolinamide
Synonyms: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₃₃H₂₂ClF₅N₆O₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 713.01
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Impurities
Boiling Point: No Data Available
Applications: Regorafenib N-Demethyl-N-4-(3-fluoro-4-methylphenoxy)-N-methylpicolinamide is an impurity of Regorafenib (R143000), which inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Dangerous Goods Info: NA
References: Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)
Peer Review Product Citations:

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