(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Catalogue number: P336925
Chemical name: (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Synonyms: (1R)-1,2,3,4-Tetrahydro-1-phenylisoquinoline; (R)-1,2,3,4-Tetrahydro-1-phenylisoquinoline; (-)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS Number: 180272-45-1
Possible CAS #: NA
Molecular form.: C₁₅H₁₅N
Appearance: Off-White to Pale Beige Solid
Melting Point: 81-83°C
Mol. Weight: 209.29
Storage: Refrigerator
Solubility: Dichloromethane (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sl
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals
Boiling Point: No Data Available
Applications: (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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