1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride

Catalogue number: P309050
Chemical name: 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride
Synonyms: 4-Keto-1-phenyl-2,3-dihydroisoquinoline Hydrochloride
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₁₅H₁₄ClNO
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 259.73
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride is a useful synthetic intermediate in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485); both metabolites of Solifenacin (S676700, HCl) which is a muscarinic M3 receptor antagonist and is used in treatment of urinary incontinence.
Dangerous Goods Info: NA
References: Naito, R., et al.: J. Med. Chem., 48, 6597 (2005); Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005); Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)
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