PHA 767491 Dihydrochloride Salt

Catalogue number: P294450
Chemical name: PHA 767491 Dihydrochloride Salt
Synonyms: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one Dihydrochloride; PHA 767491 Dihydrochloride Salt; PF-02334471;
CAS Number: NA
Possible CAS #: freebase: 845714-00-3 942425-68-5 -for HCl
Molecular form.: C₁₂H₁₃Cl₂N₃O
Appearance: Pale Yellow Solid
Melting Point: >269ºC (dec.)
Mol. Weight: 286.16
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: Chloroform, DMSO, Water
Stability: Hygroscopic
Category: Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Boiling Point: No Data Available
Applications: A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).
Dangerous Goods Info: NA
References: Anderson, D.R. et al.: J. Med. Chem., 50, 2647 (2007); Montagnoli, A. et al.: Nature Chem. Biol., 4, 357 (2008); Charych, D.H. et al.: J Cell. Biochem., 104, 1075 (2008); Jackson, P.K. et al.: Nature Chem. Biol., 4, 331 (2008);
Peer Review Product Citations:

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  Pack size Price(USD)
25mg $140.00
  Pack size Price(USD)
250mg $1120.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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