PHA-543613 Dihydrochloride

Catalogue number: P294400
Chemical name: PHA-543613 Dihydrochloride
Synonyms: N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride; PHA 543613E;
CAS Number: 478148-58-2
Possible CAS #: NA
Molecular form.: C₁₅H₁₉Cl₂N₃O₂
Appearance: Tan Solid
Melting Point: >300˚C
Mol. Weight: 344.24
Storage: Refrigerator
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Pfizer compounds
Boiling Point: No Data Available
Applications: PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer′s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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Inventory Status:   Pending QC

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