PF 477736

Catalogue number: P293850
Chemical name: PF 477736
Synonyms: (αR)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide;
CAS Number: 952021-60-2
Possible CAS #: NA
Molecular form.: C₂₂H₂₅N₇O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 419.48
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: P293850 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage.
Dangerous Goods Info: NA
References: Ashwell, et al.: Clin. Cancer Res., 14, 4032 (2008); Blasina, et al.: Mol. Cancer Ther., 7 2394 (2008); Zhang, et al.: Clin. Cancer Res., 15 4630 (2009);
Peer Review Product Citations:

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  Pack size Price(USD)
10mg $140.00
  Pack size Price(USD)
100 mg $1390.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Available in 2-3 weeks

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