PF 184

Catalogue number: P293750
Chemical name: PF 184
Synonyms: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide;
CAS Number: 1187460-81-6
Possible CAS #: NA
Molecular form.: C₃₂H₃₂ClFN₆O₄
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 619.09
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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