PF 431396

Catalogue number: P218290
Chemical name: PF 431396
Synonyms: N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide; N-Methyl-N-[2-[[[2-[(2-oxo- 2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide; PF 431396;
CAS Number: 717906-29-1
Possible CAS #: NA
Molecular form.: C₂₂H₂₁F₃N₆O₃S
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 506.5
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Inhibitors, Pfizer compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
Dangerous Goods Info: NA
References: Han, et al.: J. Biol. Chem., 284 13193 (2009), Allen, et al.: J. Med. Chem., 53 4332 (2010),
Peer Review Product Citations:

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10mg $105.00
  Pack size Price(USD)
100 mg $1025.00
Exact Weight Packaging ($75(USD) / Vial)
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