Catalogue number: P217500
Chemical name: PD-166285
Synonyms: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride;
CAS Number: 212391-63-4
Possible CAS #: NA
Molecular form.: C₂₆H₂₉Cl₄N₅O₂
Appearance: Yellow Solid
Melting Point: 239-242˚C
Mol. Weight: 585.35
Storage: Hygroscopic, Refrigerator, Under inert atmosphere
Solubility: DMSO, Methanol
Stability: Hygroscopic
Category: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators
Boiling Point: No Data Available
Applications: A broad-spectrum receptor tyrosine kinase (RTK) inhibitor which shows anti-angiogenic activity and anti-tumor efficacy in combination with photodynamic therapy (PDT).
Dangerous Goods Info: NA
References: Star, W., et al.: Cancer Res., 46, 2532 (1986), Sawutz, D., et al.: Biochem. Pharm., 51, 1631 (1996), Voest, E., et al.: Anti-Cancer Drugs, 7, 723 (1996), Connolly, C., et al.: Bioorg. Med. Chem. Lett., 7(18), 2415 (1997), Hamby, J., et al.: J. Med. Chem., 40, 2296 (1997),
Peer Review Product Citations:

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