PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate

Catalogue number: P217475
Chemical name: PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate
Synonyms: (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic Acid Bis(trifluoroacetate) Salt Hydrate; (S)-(+)-PD 123319 Bis(trifluoroacetate) Salt Hydrate;
CAS Number: NA
Possible CAS #: Freeacid: 130663-39-7; Anhydrous salt: 136676-91-0
Molecular form.: C₃₁H₃₂N₄O₃•2C₂HF₃O₂•xH₂O
Appearance: Pale Beige Solid
Melting Point: 111-114°C
Mol. Weight: 736.66
Storage: Refrigerator
Solubility: Chloroform, Methanol
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Pfizer compounds
Boiling Point: No Data Available
Applications: A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells
Dangerous Goods Info: NA
References: Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);
Peer Review Product Citations:

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Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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