PCI-34051

Catalogue number: P216600
Chemical name: PCI-34051
Synonyms: N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide; PCI 34051;
CAS Number: 950762-95-5
Possible CAS #: NA
Molecular form.: C₁₇H₁₆N₂O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 296.32
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Apoptosis, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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