PAC-1-d8

Catalogue number: P132002
Chemical name: PAC-1-d8
Synonyms: 4-(Phenylmethyl)-1-(piperazine-d8)acetic Acid (2E)-2-[[2-Hydroxy-3-(2-propen-1-yl) phenyl]methylene]hydrazide;
CAS Number: 1287241-26-2
Possible CAS #: NA
Molecular form.: C₂₃H₂₀D₈N₄O₂
Appearance: Off-White Solid
Melting Point: 129-131°C
Mol. Weight: 400.54
Storage: Refrigerator, Under Inert Atmosphere
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
Dangerous Goods Info: Not a dangerous good if item is equal too or less than 1g/ml and there is less than 100g in the package
References:
Peer Review Product Citations:

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  Pack size Price(USD)
2.5mg $125.00
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  Pack size Price(USD)
25mg $1000.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock

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