Catalogue number: P122482
Chemical name: P276-00-d4
Synonyms: 2-(2-Chlorophenyl-d4)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one; 2-(2-chlorophenyl-d4)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
CAS Number: NA
Possible CAS #: unlabeled: 920113-03-7
Molecular form.: C₂₁H₁₆D₄ClNO₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 405.86
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Inhibitors, Isotope Labelled Compounds
Boiling Point: No Data Available
Applications: P276-00-d4 is the labeled analog of P276-00 (P122480), a cyclin-dependent kinase (CDK) inhibitor. P276-00 has shown to be highly selective for cancer cells and has shown to produce potent inhibition of Cdk4-D1 activity. P276-00 also induces apoptosis in human promyelocytic leukemia (HL-60) cells.
References: Joshi, K.S., et. al.: Mol. Cancer Ther., 6, 918 (2007); Mishra, P.B., et. al.: J. Translational Med., 11, 42 (2013)
Dangerous Goods Info: NA

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