3-Oxo-4-aza-5α-androstan-17β-carboxylic Acid

Catalogue number: O869500
Chemical name: 3-Oxo-4-aza-5α-androstan-17β-carboxylic Acid
Synonyms: 3-Oxo-4-aza-5α-androstane-17-carboxylic Acid; 3-Oxo-4-aza-5α-androstane-17β-carboxylic Acid; 4-Aza-3-oxo-5α-androstane-17β-carboxylic Acid; 4-Aza-3-oxo-androstane-17β-carboxylic Acid; (5α,17β)-3-Oxo-4-azaandrostane-17-carboxylic Acid; (5α,17β)-3-Oxo-4-aza-5α-androstane-17-carboxylic Acid; (5α,17β)-3-Oxo-4-azaandrostane-17-carboxylic Acid; [4aR-(4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)]Hexadecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxylic Acid
CAS Number: 103335-55-3
Possible CAS #: NA
Molecular form.: C₁₉H₂₉NO₃
Appearance: White to Off-White Solid
Melting Point: >300°C (dec.)
Mol. Weight: 319.44
Storage: Refrigerator
Solubility: DMSO (Sparingly)
Stability: No Data Available
Category: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids,
Boiling Point: No Data Available
Applications: 3-Oxo-4-aza-5α-androstan-17β-carboxylic Acid is an impurity in the synthetic process of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.
Dangerous Goods Info: NA
References: Zhang, K. et al.: J. Chin. Pharm. Sci., 16, 233 (2007); Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),
Peer Review Product Citations:

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