Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
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NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death.
Dangerous Goods Info:
Lountos, G. et al.: Protein Sci., 18, 92 (2009); Mihich, E. et al.: Canc. Res., 29, 1056 (1969)