NSC 109555

Catalogue number: N900530
Chemical name: NSC 109555
Synonyms: 4,4’-Diacetyldiphenylurea bis(guanylhydrazone) Bismethanesulfonate; 2,2’-[Carbonylbis(imino-4,1-phenyleneethylidyne)]bis-hydrazinecarboximidamide Dimethanesulfonate
CAS Number: 15427-93-7
Possible CAS #: NA
Molecular form.: C₂₁H₃₂N₁₀O₇S₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 600.67
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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